Company Names, addresses, dates¹:
  H.W. Cole, 429 Main Street, Danville VA (18?? - c.1890s)
  Cole & Grymes, 1007 Main Street, Danville VA (c.1890s)

Notes:
Dr. Howson White Cole (1830-1910) was a druggist in Danville^2,3.
His obituary says he attended the Medical College of South Carolina, and later the Jefferson Medical College in Philadelphia, where he graduated in 1854. He was a confederate solder, and after the war started a drug business, which he stayed with until about 1905.³
The Danville city directories for 1881 & 1892 list his drug store at 429 Main Street. The 1892 directory also lists a "Cole & Grymes" at 1007 Main Street. And the 1881 city directory also has an advertisement that lists his drug store at "No 3 Masonic Building", which I beleive was at 429 Main Street.
For more information about H W Cole's drugstore, see rdricketts blog.

Bottles:

This is a clear 4.7" bottle embossed: vertical: H.W. COLE / APOTHECARY / DANVILLE VA

This is a snippet from an 1894 Sanborn Fire Insurance map, showing the drugstore at address 429 Main Street. It was part of the masonic hall building.