Company Names, addresses, dates:
  Dr. H.C. Hopkins, Bridge Street, Liberty, VA (ca.1880-ca.1890) ^1,2
  Hopkins & St. Clair, Bridge & Main Streets, Bedford City VA (ca.1890-1895) ^2,3
  Dr. H.C. Hopkins, Bridge Street, Bedford City, VA (1895-1905) ^3,6

Notes:
Dr. Henry Campbell Hopkins (1851-1905)⁴ was a pharmacist in Liberty/Bedford for 25 years. ¹

At some point, he teamed up with J. P. St. Clair to form "Hopkins & St. Clair". I don't know when that started, but the earliest newspaper mention of that name that I could find was from 1890².
In 1895, the partnership dissolved and Hopkins bought out St. Clair³, newspaper mentions of the name "Hopkins & St. Clair" continued for a couple more years.

The location of the drug store moved January of 1896⁵. It was on the NE corner of Main and Bridge Streets⁵, and moved to 116 North Bridge Street⁶.
According to Wikipedia, Liberty Virginia's name was changed to Bedford City in 1890.

Shortly after Hopkins death in 1905, the store was sold and renamed the Mosby Drug Co⁶.

This is an amber, 6" tall bottle embossed: vertical in front panel: HOPKINS & ST.CLAIR / DRUGGISTS / LIBERTY, VA.

This is a 1902, 8.5 x 5.5 inch receipt from the Dr. H.C. Hopkins drug store in Bedford City, VA. I'm making the assumption that Dr. H.C. Hopkins is the same guy who was part of the Hopkins & St. Clair drug store in the same city. Printed on the receipt is: printed on top of receipt: Prompt Payment Insures Good Credit / STATEMENT / Bedford City, VA., (u) Apr 1 1905 / Mr Floyd Gray / Bought of Dr. H.C. HOPKINS / Druggist and Apothecary, / BRIDGE STREET/ ... The purchased items on the receipt include: Cigars & Tobacco, Medicine for Cold, Soap, Dig. Pills, Carb. Acid, Paper, Medicine for Throat.