Shirey and Brown
Company Names, addresses, dates:
Shirey and Brown, Roanoke VA
Shirey & Brown had a pharmacy in Buena Vista Virginia - see this link . I don't know if Shirey & Brown had a drugstore in Roanoke, but based on the bottle below, they at least had an Arnica Cream Company there.
(more information will be added when I get around to researching this druggist)
This is a clear, 4.3" bottle embossed:
vertical: Shirey and Brown / ARNICA CREAM / ARNICA CREAM CO. INC. / ROANOKE, VA.